Articles

A pilot study exploring the association of morphological changes with 5-HTTLPR polymorphism in OCD patients

Clinical and pharmacological studies of obsessive-compulsive disorder (OCD) have suggested that the serotonergic systems are involved in the pathogenesis, while structural imaging studies have found some neuro...

Authors: Shinichi Honda, Tomohiro Nakao, Hiroshi Mitsuyasu, Kayo Okada, Leo Gotoh, Mayumi Tomita, Hirokuni Sanematsu, Keitaro Murayama, Keisuke Ikari, Masumi Kuwano, Takashi Yoshiura, Hiroaki Kawasaki and Shigenobu Kanba

Antidepressive response of inpatients with major depression to adjuvant occupational therapy: a case–control study

Despite marked costs and limited evidence regarding effectiveness, occupational therapy (OT) is widely applied in psychiatric settings and financed by health insurance companies in European countries. This pil...

Authors: Marc-Andreas Edel, Brian Blackwell, Markus Schaub, Barbara Emons, Tanja Fox, Friederike Tornau, Bernward Vieten, Patrik Roser, Ida Sibylle Haussleiter and Georg Juckel

The association between altered lipid profile and suicide attempt among Tunisian patients with schizophrenia

There have been many studies on psychiatric disorders, but very little is known about the biology of suicide with schizophrenia. In the present study, we are looking for a possible connection between altered l...

Authors: Rym Mensi, Amal Messaoud, Ahmed Mhallah, Islem Azizi, Walid Haj Salah, Wahiba Douki, Mohamed Fadhel Najjar and Lotfi Gaha

Suicidal ideation and suicide attempts among asthma

The present study aimed to investigate the mental health status in patients with asthma and assess the effects of asthma on suicidal ideation and attempts using a representative sample from Korea.

Authors: Jae Ho Chung, Sun- Hyun Kim and Yong Won Lee

The newer Opioid Agonist Treatment with lower substitutive opiate doses is associated with better toxicology outcome than the older Harm Reduction Treatment

Charge-free heroin use disorder treatment in Italy follows two main approaches, i.e., harm reduction treatment (HRT) strategy in community low-threshold facilities for drug addiction and opioid agonist treatme...

Authors: Jacopo V. Bizzarri, Valentina Casetti, Livia Sanna, Angelo Giovanni Icro Maremmani, Luca Rovai, Silvia Bacciardi, Daria Piacentino, Andreas Conca and Icro Maremmani

Resilience and burnout status among nurses working in oncology

This study aimed to identify the resilience and burnout status of nurses working in the field of oncology.

Authors: Sevinc Kutluturkan, Elif Sozeri, Nese Uysal and Figen Bay

Maternal bonding styles in smokers and non-smokers: a comparative study

Parental bonding has been implicated in smoking behavior, and the quality of maternal bonding (MB) has been associated with poor mental health and substance use. However, little is known about the association ...

Authors: Iren Csala, Monika Elemery, Fruzsina Martinovszky, Peter Dome, Balazs Dome, Gabor Faludi, Imola Sandor, Zsuzsa Gyorffy, Emma Birkas and Judit Lazary

Validation of the Italian version of the dissociative experience scale for adolescents and young adults

The Dissociative Experience Scale for adolescent (A-DES), a 30-item, multidimensional, self-administered questionnaire, was validated using a large sample of American young people sample. We reported the lingu...

Authors: Concetta De Pasquale, Federica Sciacca and Zira Hichy

Serum fluoxetine and norfluoxetine levels support the safety of fluoxetine in overdose

Previous literature has found fluoxetine to be relatively safe in overdose. This study hopes to examine this idea along with support from published pharmacokinetic information including serum fluoxetine and no...

Authors: Stephanie Pope and Solomon G. Zaraa

The impact of psychopathological subtypes on retention rate of patients with substance use disorder entering residential therapeutic community treatment

A specific psychopathology of addiction has been proposed and described using the self-report symptom inventory (SCL-90), leading to a 5-factor aggregation of psychological/psychiatric symptoms: ‘worthlessness...

Authors: Angelo G. I. Maremmani, Pier Paolo Pani, Emanuela Trogu, Federica Vigna-Taglianti, Federica Mathis, Roberto Diecidue, Ursula Kirchmayer, Laura Amato, Joli Ghibaudi, Antonella Camposeragna, Alessio Saponaro, Marina Davoli, Fabrizio Faggiano and Icro Maremmani

Personality traits, gender roles and sexual behaviours of young adult males

Previous studies have shown that personality characteristics affect sexual functioning. The aim of this exploratory study was to assess and describe the relationship between global personality traits and the s...

Authors: Jacek Kurpisz, Monika Mak, Michał Lew-Starowicz, Krzysztof Nowosielski, Przemysław Bieńkowski, Robert Kowalczyk, Błażej Misiak, Dorota Frydecka and Jerzy Samochowiec

Effect of mirtazapine versus selective serotonin reuptake inhibitors on benzodiazepine use in patients with major depressive disorder: a pragmatic, multicenter, open-label, randomized, active-controlled, 24-week trial

This study aimed to evaluate whether selecting mirtazapine as the first choice for current depressive episode instead of selective serotonin reuptake inhibitors (SSRIs) reduces benzodiazepine use in patients w...

Authors: Tasuku Hashimoto, Akihiro Shiina, Tadashi Hasegawa, Hiroshi Kimura, Yasunori Oda, Tomihisa Niitsu, Masatomo Ishikawa, Masumi Tachibana, Katsumasa Muneoka, Satoshi Matsuki, Michiko Nakazato and Masaomi Iyo

Regional cortical thinning of the orbitofrontal cortex in medication-naïve female patients with major depressive disorder is not associated with MAOA-uVNTR polymorphism

Orbitofrontal cortex alterations have been suggested to underlie the impaired mood regulation in depression. MAOA-uVNTR (monoamine oxidase A-upstream variable number of tandem repeats) polymorphism has been repor...

Authors: Eunsoo Won, Sunyoung Choi, June Kang, Min-Soo Lee and Byung-Joo Ham

Analysis of personality traits and their influence on the quality of life of postmenopausal women with regard to genetic factors

Quality of life can be perceived as a subjective assessment of different aspects of human functioning. Personality is a factor which determines actions taken by individuals and their tendency to perceive reali...

Authors: Daria Schneider-Matyka, Anna Jurczak, Agnieszka Samochowiec, Beata Karakiewicz, Małgorzata Szkup, Anna Grzywacz and Elżbieta Grochans

Intact social cognitive processes in outpatients with anorexia nervosa: a pilot study

The aim of the study was to assess social cognition in community patients suffering from anorexia nervosa (AN) compared to healthy controls.

Authors: Katarzyna Kucharska, Julia Jeschke and Reza Mafi

Multi-regression analysis revealed a relationship between l-serine and methionine, a component of one-carbon metabolism, in the normal control but not in the schizophrenia

Alterations in one-carbon metabolism (OCM) have been observed in patients with schizophrenia (SZ), but a comprehensive study of OCM has not yet been conducted. A carbon atom is transferred from l-serine to methio...

Authors: Yumiko Takano, Yuji Ozeki, Masae Sekine, Kumiko Fujii, Takashi Watanabe, Hiroaki Okayasu, Takahiro Shinozaki, Akiko Aoki, Kazufumi Akiyama, Hiroshi Homma and Kazutaka Shimoda

A prospective hospital study of alcohol use disorders, comorbid psychiatric conditions and withdrawal prognosis

The objective of this study was to describe the profile and alcoholic status of a population with alcohol use disorders (AUD) requesting help from a psychiatric hospital to stop drinking, as well as their clin...

Authors: Philippe Nubukpo, Murielle Girard, Jean-Marie Sengelen, Sophie Bonnefond, Aurélien Varnoux, Benoît Marin and Dominique Malauzat

Twice-weekly aripiprazole for treating children and adolescents with tic disorder, a randomized controlled clinical trial

Treating tic disorder is challenging. No trial has ever examined whether twice weekly aripiprazole is effective for treating tic disorders.

Authors: Ahmad Ghanizadeh

Pharmacotherapy and group cognitive behavioral therapy enhance follow-up treatment duration in gambling disorder patients

Longer treatment duration is important for the successful treatment of gambling disorder (GD). This retrospective study investigated the factors and interventions that might enhance treatment duration in GD p...

Authors: Sam-Wook Choi, Young-Chul Shin, HyunChul Youn, Se-Won Lim and Juwon Ha

Relationship of suicide rates with climate and economic variables in Europe during 2000–2012

It is well known that suicidal rates vary considerably among European countries and the reasons for this are unknown, although several theories have been proposed. The effect of economic variables has been ext...

Authors: Konstantinos N. Fountoulakis, Isaia Chatzikosta, Konstantinos Pastiadis, Prodromos Zanis, Wolfram Kawohl, Ad J. F. M. Kerkhof, Alvydas Navickas, Cyril Höschl, Dusica Lecic-Tosevski, Eliot Sorel, Elmars Rancans, Eva Palova, Georg Juckel, Goran Isacsson, Helena Korosec Jagodic, Ileana Botezat-Antonescu…

CT genotype of 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is protector factor of major depressive disorder in the Tunisian population: a case control study

Major depressive disorder (MDD) is a common psychiatric disorder with considerable mortality. Death from unnatural causes, largely suicidal or quasi-suicidal, has a particularly high risk for the functional di...

Authors: Mohamed Amine Sayadi, Ons Achour, Asma Ezzaher, Ilham Hellara, Asma Omezzine, Wahiba Douki, Ali Bousslama, Lotfi Gaha and Mohamed Fadhel Najjar

Hyperthymic affective temperament and hypertension are independent determinants of serum brain-derived neurotrophic factor level

Brain-derived neurotrophic factor (BDNF) has neuroprotective, proangiogenic and myogenic effects and, therefore, possibly acts as a psychosomatic mediator. Here, we measured serum BDNF (seBDNF) level in hypert...

Authors: János Nemcsik, Andrea László, Lilla Lénárt, Dániel Eörsi, Péter Torzsa, Beáta Kőrösi, Orsolya Cseprekál, András Tislér, Ádám Tabák, Xenia Gonda, Zoltán Rihmer, Judit Hodrea, Zsófia Nemcsik-Bencze and Andrea Fekete

Development and validation of a stock addiction inventory (SAI)

Investing in financial markets is promoted and protected by the government as an essential economic activity, but can turn into a gambling addiction problem. Until now, few scales have widely been used to iden...

Authors: HyunChul Youn, Jung-Seok Choi, Dai-Jin Kim and Sam-Wook Choi

Psychotic spectrum symptoms across the lifespan are related to lifetime suicidality among 147 patients with bipolar I or major depressive disorder

Conflicting evidence exists about the relationship between psychotic symptoms and suicidality in mood disorders. We aimed to investigate the lifetime suicidality and its relationship with dimensions of the psy...

Authors: Camilla Gesi, Claudia Carmassi, Mario Miniati, Antonella Benvenuti, Gabriele Massimetti and Liliana Dell’Osso

Increased arterial stiffness parameters in panic disorder patients in long term treatment period

The relationship between mental stress and cardiovascular disease has been shown in several studies. Panic disorder (PD) is also associated with cardiovascular disease due to increased risk of myocardial infar...

Authors: Omer Yanartas, Murat Sunbul, Zeynep Senkal, Erdal Durmus, Tarik Kivrak, Nilufer Subasi, Gulhan Karaer, Serhat Ergun, Ibrahim Sari and Kemal Sayar

Psychopathology of addiction: May a SCL-90-based five dimensions structure be applied irrespectively of the involved drug?

We previously found a five cluster of psychological symptoms in heroin use disorder (HUD) patients: ‘worthlessness-being trapped’, ‘somatic-symptoms’, ‘sensitivity-psychoticism’, ‘panic-anxiety’, and ‘violence...

Authors: Pier Paolo Pani, Angelo G. I. Maremmani, Emanuela Trogu, Federica Vigna-Taglianti, Federica Mathis, Roberto Diecidue, Ursula Kirchmayer, Laura Amato, Joli Ghibaudi, Antonella Camposeragna, Alessio Saponaro, Marina Davoli, Fabrizio Faggiano and Icro Maremmani

Relationship between the lesion location of acute ischemic stroke and early depressive symptoms in Japanese patients

Approximately one-third of stroke survivors suffer from post-stroke depression (PSD) in the acute or chronic stages. The presence of PSD in the acute stage after stroke is reportedly associated with poor patie...

Authors: Norifumi Metoki, Norio Sugawara, Joji Hagii, Shin Saito, Hiroshi Shiroto, Tetsu Tomita, Minoru Yasujima, Ken Okumura and Norio Yasui-Furukori

Link of dysfunctional attitudes with the negative self-model

Beck’s cognitive theory postulates that dysfunctional attitudes predisposing to depression are formed by early negative experiences. Meanwhile, Bowlby’s attachment theory contends that distorted working models...

Authors: Koichi Otani, Akihito Suzuki, Yoshihiko Matsumoto and Masanori Enokido

The genetic and environmental structure of the character sub-scales of the temperament and character inventory in adolescence

The character higher order scales (self-directedness, cooperativeness, and self-transcendence) in the temperament and character inventory are important general measures of health and well-being [Mens Sana Mono...

Authors: Nigel Lester, Danilo Garcia, Sebastian Lundström, Sven Brändström, Maria Råstam, Nóra Kerekes, Thomas Nilsson, C. Robert Cloninger and Henrik Anckarsäter

Bipolar II compared with bipolar I disorder: baseline characteristics and treatment response to quetiapine in a pooled analysis of five placebo-controlled clinical trials of acute bipolar depression

Bipolar I and II represent the most common and severe subtypes of bipolar disorder. Although bipolar I disorder is relatively well studied, the clinical characteristics and response to treatment of patients wi...

Authors: Catherine Datto, William J. Pottorf, Louisa Feeley, Scott LaPorte and Charlie Liss

Sensory cognitive abnormalities of pain in autism spectrum disorder: a case–control study

The Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) recently included sensory processing abnormalities in the diagnostic criteria for individuals with autism spectrum disorder (ASD)...

Authors: Yuka Yasuda, Ryota Hashimoto, Aya Nakae, Hongling Kang, Kazutaka Ohi, Hidenaga Yamamori, Michiko Fujimoto, Satoshi Hagihira and Masatoshi Takeda

Workplace bullying and general health status among the nursing staff of Greek public hospitals

The arduous emotional and physical nurses’ work, the gradual nursing staff cutbacks and the lack of recognition that nurses feel regarding their skills and overall capabilities are some of the factors that act...

Authors: Christina Karatza, Sofia Zyga, Styliani Tziaferi and Panagiotis Prezerakos

Rhabdomyolysis after lamotrigine overdose: a case report and review of the literature

Lamotrigine is an effective anticonvulsant drug that has also been demonstrated to be effective in the treatment of bipolar disorder. We report a case of rhabdomyolysis after intentional overdose in a woman ag...

Authors: Sokratis E. Karaoulanis, Markos Syngelakis and Konstantinos Fokas

Physician perception regarding side-effect profile at the onset of antidepressant treatment: a survey of Israeli psychiatrists and primary care physicians

One of the major factors affecting treatment compliance and outcome in patients is the wide range of side effects (SEs) associated with antidepressants. In the present study, we aimed to assess the extent to w...

Authors: Uri Nitzan, Tal Bekerman, Gideon Becker, Pesach Lichtenberg, Shaul Lev-Ran, Garry Walter, Hagai Maoz and Yuval Bloch

Factor structure of the Chinese version of the geriatric anxiety inventory

As China’s population ages, the mental health of older people has been increasingly focused on by academic circles.

Authors: Ming Guan

Utility of the Neurobehavioral Cognitive Status Examination (COGNISTAT) in differentiating between depressive states in late-life depression and late-onset Alzheimer’s disease: a preliminary study

It is often difficult to differentiate between the depressive states seen in late-life depression and late-onset Alzheimer’ disease (AD) in the clinical setting.

Authors: Yoshiaki Tsuruoka, Michio Takahashi, Masatoshi Suzuki, Koichi Sato and Yukihiko Shirayama

Erratum to: Integrating technology into cognitive behavior therapy for adolescent depression: a pilot study

Authors: Kenneth A. Kobak, James C. Mundt and Betsy Kennard

Serum levels of brain-derived neurotrophic factor (BDNF), proBDNF and plasma 3-methoxy-4-hydroxyphenylglycol levels in chronic schizophrenia

We investigated the serum levels of brain-derived neurotrophic factor (BDNF), proBDNF and plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) levels in patients with chronic schizophrenia.

Authors: Reiji Yoshimura, Hikaru Hori, Asuka Katsuki, Kiyokazu Atake and Jun Nakamura

The characteristics of the suicide attempter according to the onset time of the suicidal ideation

To determine the timing of development of suicidal ideation and factors associated therewith in suicide attempters who required psychiatric emergency treatment.

Authors: Kotaro Otsuka, Hikaru Nakamura, Kaoru Kudo, Jin Endo, Katsumi Sanjo, Kentaro Fukumoto, Katsuhito Hoshi, Junko Yagi and Akio Sakai

Digital comparison of healthy young adults and borderline patients engaged in non-suicidal self-injury

It still remains unclear whether non-suicidal self-injury (NSSI) in young adult populations represents an actual symptom leading to psychiatric illness, constitutes a disorder itself or is rather a cultural pe...

Authors: Rachel Stroehmer, Marc A. Edel, Steffi Pott, Georg Juckel and Ida S. Haussleiter

Neurocognitive features in male patients with schizophrenia exhibiting serious violence: a case control study

The relationship between violence and neurocognitive function in schizophrenia is unclear. We examined the backgrounds and neurocognitive functions of violent and nonviolent patients with schizophrenia to iden...

Authors: Hiroko Kashiwagi, Noriomi Kuroki, Satoru Ikezawa, Masateru Matsushita, Masanori Ishikawa, Kazuyuki Nakagome, Naotsugu Hirabayashi and Manabu Ikeda

Serotonin transporter clustering in blood lymphocytes predicts the outcome on anhedonia scores in naïve depressive patients treated with antidepressant medication

We have shown that serotonin transporter (SERT) clustering in blood lymphocytes is altered in major depression and correlates with pharmacological therapeutic responses measured with the Hamilton scale. In the...

Authors: Tania Rivera-Baltanas, Roberto Carlos Agis-Balboa, Raquel Romay-Tallon, Lisa E. Kalynchuk, Jose Manuel Olivares and Hector J. Caruncho

A clinical comparison of schizophrenia with and without pre-onset cannabis use disorder: a retrospective cohort study using categorical and dimensional approaches

A high prevalence of cannabis use disorder has been reported in subjects suffering from schizophrenia, fuelling intense debate about whether schizophrenia with pre-onset cannabis use disorder may be a distinc...

Authors: Samuel Sarrazin, Florence Louppe, Raphael Doukhan and Franck Schürhoff

Attachment, recalled parental rearing, and ADHD symptoms predict emotion processing and alexithymia in adults with ADHD

The aim of the aricle is to study the relationship between attachment, parental rearing behavior, and (infant and current) ADHD symptoms with emotion processing and alexithymia in adults with ADHD.

Authors: Marc-Andreas Edel, Susanne Edel, Marie Krüger, Hans-Jörg Assion, Georg Juckel and Martin Brüne

The neurocognitive functioning in bipolar disorder: a systematic review of data

During the last decades, there have been many different opinions concerning the neurocognitive function in Bipolar disorder (BD). The aim of the current study was to perform a systematic review of the literatu...

Authors: Eirini Tsitsipa and Konstantinos N. Fountoulakis

Cognitive impairment in manic bipolar patients: important, understated, significant aspects

Bipolar disorder is a chronic mood disorder with episodic progress and high relapse rate. Growing evidence suggests that individuals with bipolar disorder display cognitive impairment which persists even throu...

Authors: Mădălina Vrabie, Victor Marinescu, Anca Talaşman, Oana Tăutu, Eduard Drima and Ioana Micluţia

Disability assessment as an outcome measure: a comparative study of Nigerian outpatients with schizophrenia and healthy control

Schizophrenia is a chronic mental disorder that leads to disability in several aspects of the individual’s personal, social, and occupational functioning. This study assesses and compares the level of disabili...

Authors: Adesanmi Akinsulore, Boladale M. Mapayi, Olutayo O. Aloba, Ibidunni Oloniniyi, Femi O. Fatoye and Roger O. A. Makanjuola

Sex differences in plasma clozapine and norclozapine concentrations in clinical practice and in relation to body mass index and plasma glucose concentrations: a retrospective survey

Clozapine is widely prescribed and, although effective, can cause weight gain and dysglycemia. The dysmetabolic effects of clozapine are thought to be more prevalent in women with this gender on average attain...

Authors: Simon G. Anderson, Mark Livingston, Lewis Couchman, Daniel J. Smith, Moira Connolly, Joan Miller, Robert J. Flanagan and A. H. Heald

Neurotoxic syndrome induced by clomipramine plus risperidone in a patient with autistic spectrum disorder: serotonin or neuroleptic malignant syndrome?

To the best of our knowledge, there are no case studies of serotonin syndrome (SS) in patients with autism spectrum disorder. We report the case of a 33-year-old male who presented SS under the combined use of...

Authors: Kalliopi N. Nikolaou, Rossetos Gournellis, Ioannis Michopoulos, Georgios Dervenoulas, Christos Christodoulou and Athanasios Douzenis

Integrating technology into cognitive behavior therapy for adolescent depression: a pilot study

Rapid advances in information technology and telecommunications have resulted in a dramatic increase in the use of mobile devices and the internet to enhance and facilitate access to treatment. Cognitive beha...

Authors: Kenneth A. Kobak, James C. Mundt and Betsy Kennard