Randomized clinical trial of low dose suramin intravenous infusions for treatment of autism spectrum disorder

Table 4 Observed plasma concentrations

Dose Group (mg/kg)		Parameter
		Concentration 1 h after end of infusion						C_trough
		Day						Day
		1		28		56		28		56
		ug/mL	(ug/mL)/mg	ug/mL	(ug/mL)/mg	ug/mL	(ug/mL)/mg	ug/mL	(ug/mL)/mg	ug/mL	(ug/mL)/mg
10	N	15	15	15	15	15	15	15	15	15	15
	Mean	229	0.838	157	0.605	164	0.640	4.31	0.017	7.96	0.030
	Min	120	0.40	111	0.41	133	0.36	3.12	0.01	5.33	0.02
	Median	168	0.61	160	0.58	167	0.61	4.16	0.02	7.28	0.03
	Max	1150	3.52	189	0.84	200	0.90	7.07	0.02	11.4	0.04
	CV%	112	92.1	15.3	22.2	11.3	23.5	23.8	26.4	22.9	22.7
	Geometric mean	182	0.692	155	0.591	163	0.622	4.21	0.016	7.78	0.030
	CV% geometric mean	59.7	58.6	16.1	22.6	11.3	25.4	22.0	29.0	22.5	25.8
20	N	18	18	16	16	15	15	16	16	15	15
	Mean	328	0.51	327	0.53	332	0.52	11.0	0.018	21.1	0.033
	Min	214	0.15	193	0.12	172	0.13	6.16	0.00	7.60	0.01
	Median	344	0.52	330	0.54	353	0.58	11.3	0.02	24.40	0.04
	Max	439	0.92	470	0.97	459	0.77	14.3	0.03	30.20	0.05
	CV%	20.5	43.4	28.0	44.4	25.8	36.4	18.8	34.0	35.9	45.0
	Geometric mean	321	0.456	314	0.47	320	0.47	10.8	0.016	19.4	0.029
	CV% geometric mean	22.3	52.8	29.9	59.8	30.0	55.6	21.2	51.7	48.0	71.4

ISSN: 1744-859X