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Table 1 General characteristics of included studies

From: Malondialdehyde concentrations in obsessive–compulsive disorder: a systematic review and meta-analysis

Country (ethnicity)

Control

Case

OCD diagnosis

Method of MDA assay

Sample size (Ca/Co)

Age (Ca/Co)

Gender (Ca/Co)

Severity

SYB

Duration (years)

Match

Quality assessment

Result

Reference

Mean

SD

Mean

SD

F

M

Mild

Mo

Severe

Vs

Iraq (Caucasian)

1.15 nmol/ml

1

1.67

3.28

NM

ELISA

(60/30)

18–68 years

43

47

NM

NM

NM

NM

NM

NM

NM

3

Mohamed et al. 2020

India (Asian)

3.85 unit/mg of protein

1.83

1.02

0.5

ICD-10-DCR

Ohkawa

(30/30)

(23.86 ± 6.96/28.56)

(19/19

(11/11)

NM

NM

NM

NM

23.8 ± 1.90

3.9 ± 2.9

Age and gender

6

Shrivtastava et al. 2017

Turkey (Caucasian)

10.32 nmol/ml

1.51

5.13

0.98

DSM IV

Ohkawa

(102/104)

(38.75 ± 10.88/36.39 ± 10.35)

(82/57

(20/47)

NM

NM

NM

NM

NM

11.26 ± 8.56

Age and gender

5

Orhan et al. [34]

Bangladesh (Asian)

5.7 nmol/ml

1.7

4.3

1.2

DSM IV

Satoh

(48/48)

(24.7 ± 4.6/21.3 ± 1)

(6/6)

(42/42)

16

18

14

NM

NM

 < 5 30,

5–10 8,

 > 10 10

Age, gender and socioeconomic status

7

Shohag et al. [22]

India (Asian)

4.89 nmol/ml

0.22

4.07

0.22

DSM IV

Satoh

(20/20)

(29.70 ± 8.35/30.50 ± 9.34)

(0/0)

(20/20)

NM

NM

NM

NM

NM

Least of a year

Age and gender

5

Behl et al. [32]

Turkey (Caucasian)

10.139 nmol/g Hb

8.68

6.032

6.57

DSM IV

Jain

(28/28)

(28.28 ± 5.41/28.85 ± 5.54)

(18/18

(10/10)

5

11

9

3

22.47 ± 5.39

NM

Gender

6

Ozdemir et al. [26]

Turkey (Caucasian)

0.285 μmol/g Hb

0.05

0.198

0.03

DSM IV

Jain

(30/30)

(29.2 ± 6.2/ 29.2 ± 7.2)

(22/21)

(8/9)

NM

NM

NM

NM

NM

NM

Age and gender

6

Ersan et al. [23]

Turkey (Caucasian)

4.15 nmol/ml

0.73

2.5

0.41

DSM IV

Satoh

(34/32)

(25.72 ± 7.04/29.13 ± 9.19)

(22/19)

(12/13)

4

9

18

3

NM

5.35 ± 3.12

Age and gender

6

Kuloglu et al. [33]

India (Asian)

12.63 nmol/ml RBC

2.91

8.84

0.46

DSM IV

Wills

(15/15)

NM

NM

NM

NM

NM

NM

NM

NM

NM

Age and gender

3

Kurup et al. [27]

  1. Ca case, Co control, SYB score of Y-BOCS, Mo moderate, Vs very severe, F female, M male, NM not mentioned by the authors/in the article