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Table 4 Associations between DRD2 and ANKK1 gene polymorphisms and selected clinical parameters in schizophrenic patients (N = 198)

From: Association between DRD2 and ANKK1 polymorphisms with the deficit syndrome in schizophrenia

Parameter rs1799732 rs6276 rs1800497
χ2* H# p χ2* H# p χ2* H# p
Psychiatric illness in the family 0.08 0.777 9.54 0.002 1.98 0.159
Neurological illness in the family 0.06 0.807 1.08 0.299 2.52 0.112
Age of onset (years) 0.85 0.653 1.01 0.603 0.98 0.611
Time delay from onset to diagnosis 4.75 0.093 0.03 0.987 2.41 0.299
 < 1 month
 1–6 months
 > 6 months
Withdrawal of symptoms after neuroleptics 0.99 0.321 1.57 0.211 1.61 0.204
Number of psychiatric hospitalizations 2.97 0.226 0.41 0.814 3.65 0.161
Longest episode (weeks) 1.25 0.535 3.90 0.142 0.52 0.770
Clinical course 0.01 0.996 2.00 0.368 1.04 0.596
 Episodes of relapses and remissions
 Chronic course
 Chronic course with social withdrawal
MMSE 3.07 0.216 2.18 0.337 0.47 0.789
PANSS
 Total 2.51 0.285 0.33 0.846 0.70 0.705
 Positive 4.83 0.090 0.67 0.717 0.76 0.684
 Negative 1.32 0.517 1.34 0.512 2.64 0.267
 General 2.37 0.306 0.02 0.992 0.50 0.779
CGI-SCH
 Total 0.70 0.703 0.38 0.828 0.62 0.734
 Positive 0.62 0.734 1.54 0.462 1.80 0.406
 Negative 0.40 0.819 0.97 0.615 0.83 0.66
 Depressive 0.93 0.627 0.82 0.66 1.73 0.421
 Cognitive 0.66 0.718 0.73 0.693 2.42 0.298
 Total severity of schizophrenia 0.83 0.66 0.27 0.872 0.03 0.987
SDS 0.16 0.924 0.85 0.654 1.78 0.411
  1. χ2 coefficient for allele comparison in Pearson’s test (genotype comparisons were abandoned due to the small numbers expected for certain genotypes)
  2. #H coefficient, Kruskal–Wallis test for genotype comparison