Association between DRD2 and ANKK1 polymorphisms with the deficit syndrome in schizophrenia

Table 4 Associations between DRD2 and ANKK1 gene polymorphisms and selected clinical parameters in schizophrenic patients (N = 198)

Parameter	rs1799732		rs6276		rs1800497
Parameter	χ²* H^#	p	χ²* H^#	p	χ²* H^#	p
Psychiatric illness in the family	0.08	0.777	9.54	0.002	1.98	0.159
Neurological illness in the family	0.06	0.807	1.08	0.299	2.52	0.112
Age of onset (years)	0.85	0.653	1.01	0.603	0.98	0.611
Time delay from onset to diagnosis	4.75	0.093	0.03	0.987	2.41	0.299
< 1 month
1–6 months
> 6 months
Withdrawal of symptoms after neuroleptics	0.99	0.321	1.57	0.211	1.61	0.204
Number of psychiatric hospitalizations	2.97	0.226	0.41	0.814	3.65	0.161
Longest episode (weeks)	1.25	0.535	3.90	0.142	0.52	0.770
Clinical course	0.01	0.996	2.00	0.368	1.04	0.596
Episodes of relapses and remissions
Chronic course
Chronic course with social withdrawal
MMSE	3.07	0.216	2.18	0.337	0.47	0.789
PANSS
Total	2.51	0.285	0.33	0.846	0.70	0.705
Positive	4.83	0.090	0.67	0.717	0.76	0.684
Negative	1.32	0.517	1.34	0.512	2.64	0.267
General	2.37	0.306	0.02	0.992	0.50	0.779
CGI-SCH
Total	0.70	0.703	0.38	0.828	0.62	0.734
Positive	0.62	0.734	1.54	0.462	1.80	0.406
Negative	0.40	0.819	0.97	0.615	0.83	0.66
Depressive	0.93	0.627	0.82	0.66	1.73	0.421
Cognitive	0.66	0.718	0.73	0.693	2.42	0.298
Total severity of schizophrenia	0.83	0.66	0.27	0.872	0.03	0.987
SDS	0.16	0.924	0.85	0.654	1.78	0.411

* χ² coefficient for allele comparison in Pearson’s test (genotype comparisons were abandoned due to the small numbers expected for certain genotypes)
^#H coefficient, Kruskal–Wallis test for genotype comparison

ISSN: 1744-859X