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Table 2 The results of enrichment analysis for pathways, molecular functions, cellular components and brain regions involved in the pathogenesis of both OCD and BD

From: How obsessive–compulsive and bipolar disorders meet each other? An integrative gene-based enrichment approach

 Pathway full nameKEGG IDFDRBetweenness centrality
1Dopaminergic synapsehsa047283.86E−080.13604918
2cAMP signaling pathwayhsa040241.19E−060.12989786
3Serotonergic synapsehsa047260.0001120.0838125
4Calcium signaling pathwayhsa040200.0009790.07812904
5Glutamatergic synapsehsa047240.0011580.04450784
6GABAergic synapsehsa047270.0055430.03118593
7Retrograde endocannabinoid signalinghsa047230.007530.04801305
 Molecular functionsGene ontology (GO) IDFDRBetweenness centrality
1Dopamine bindingGO:00352403.59E−100.011851
2Dopamine neurotransmitter receptor activity, coupled via GsGO:00015889.72E−090.0047987
3Extracellular-glutamate-gated ion channel activityGO:00052342.06E−060
4G-protein-coupled amine receptor activityGO:00082270.0001420.00705387
5Amino acid bindingGO:00165970.0002110.02687112
6Kainate-selective glutamate receptor activityGO:00152770.0015170
7Monoamine transmembrane transporter activityGO:00085040.0048290.00237254
8Serotonin bindingGO:00513780.0048295.53E−04
9Ammonium transmembrane transporter activityGO:00085190.0287460.00237254
10Serotonin receptor activityGO:00995890.0287465.53E−04
 Cellular componentsGene ontology (GO) IDFDRBetweenness centrality
1DendriteGO:00304250.0001510.07980464
2Axon partGO:00332670.0002150.03089599
3Postsynaptic densityGO:00140690.0002430.05051219
4Ionotropic glutamate receptor complexGO:00083280.0011480.0055914
5Membrane raftGO:00451210.0011580.05504978
6Cation channel complexGO:00347030.0033350.02751275
7PerikaryonGO:00432040.010230.00847745
8Synaptic vesicleGO:00080210.0136920.01103456
 Brain regions FDRBetweenness centrality
1Cortex 0.0080.22937063
2Striatum 0.0080.1299988
3Hippocampus 0.0080.07421981