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Table 1 The results of enrichment analysis for genes involved in the pathogenesis of both OCD and BD

From: How obsessive–compulsive and bipolar disorders meet each other? An integrative gene-based enrichment approach

 Gene full official nameHGNC symbolBetweenness centrality
1Calcium voltage-gated channel subunit alpha1 CCACNA1C0.338153
2Glutamate ionotropic receptor AMPA-type subunit 1 GRIA10.1574122
3Dopamine receptor D2DRD20.1136524
4Nitric oxide synthase 1NOS10.0903783
5Solute carrier family 18 member A1SLC18A10.0661232
65-Hydroxytryptamine receptor 2AHTR2A0.0660831
7Dopamine receptor D1DRD10.0500920
8Glutamate ionotropic receptor kainate-type subunit 2GRIK20.0481045
9Dopamine receptor D5DRD50.0458659
105-Hydroxytryptamine receptor 1A, serotonin receptorHTR1A0.0443705
11Glutamate ionotropic receptor NMDA-type subunit 2BGRIN2B0.036738
12Solute carrier family 6 member 4SLC6A40.020317
13Glutamate ionotropic receptor kainate-type subunit 3GRIK30.038491
14Dopamine receptor D3DRD30.017168
15Cannabinoid receptor 1CNR10.007217
16Adrenoceptor alpha 1AADRA1A0.006255
17Brain-derived neurotrophic factorBDNF0.005617
18Tryptophan hydroxylase 2TPH20.0045508
19Dopamine receptor D4DRD40.004232
20Glutamate decarboxylase 1GAD10.003155
21Gamma-aminobutyric acid type A receptor alpha1 subunit GABRA10.001786
22Neurotrophic receptor tyrosine kinase 2NTRK20.001023
23Angiotensin I converting enzymeACE0
24Ataxin 1ATXN10
25Cholinergic receptor nicotinic alpha 7 subunitCHRNA70
26Corticotropin-releasing hormone receptor 2CRHR20
27Dopamine beta-hydroxylaseDBH0
28Ephrin A5EFNA50
29Glutamic acid decarboxylase 2GAD20
30Glutamate ionotropic receptor NMDA-type subunit 2AGRIN2A0
315-Hydroxytryptamine receptor 2CHTR2C0
325-Hydroxytryptamine receptor 3AHTR3A0
33Olfactomedin 1OLFM10
34Tumor necrosis factorTNF0