| Event number/N | HR (95% CI) | p value |
---|---|---|---|
Overall | 13,124/355,942 | 1.29 (1.22, 1.38) | < 0.0001 |
Year | |||
 2008 | 3331/59,997 | 1.33 (1.19, 1.49) | < 0.0001 |
 2009 | 2684/49,834 | 1.25 (1.09, 1.44) | 0.0015 |
 2010 | 2076/44,272 | 1.33 (1.14, 1.55) | 0.0003 |
 2011 | 1534/44,567 | 1.20 (0.99, 1.45) | 0.0644 |
 2012 | 1239/43,556 | 1.48 (1.20, 1.82) | 0.0002 |
 2013 | 1058/41,992 | 1.49 (1.18, 1.87) | 0.0008 |
 2014 | 775/40,490 | 1.47 (1.09, 1.98) | 0.0105 |
 2015 | 427/31,234 | 2.28 (1.57, 3.31) | < 0.0001 |
Gender | |||
 Women | 6837/222,165 | 1.34 (1.23, 1.46) | < 0.0001 |
 Men | 6287/133,777 | 1.25 (1.14, 1.37) | < 0.0001 |
Age group | |||
 18–24 | 108/40,681 | 1.50 (0.84, 2.68) | 0.1698 |
 25–34 | 232/68,137 | 2.35 (1.69, 3.26) | < 0.0001 |
 35–44 | 486/69,687 | 1.38 (1.04, 1.83) | 0.0282 |
 45–54 | 1032/63,632 | 1.31 (1.07, 1.61) | 0.0097 |
 55–64 | 1745/46,306 | 1.35 (1.15, 1.57) | 0.0001 |
 65+ | 9521/67,499 | 1.24 (1.15, 1.34) | < 0.0001 |
Depression subtype | |||
 Major depressive disorder (ICD 296.2, 296.3×) | 4358/130,379 | 1.33 (1.20, 1.47) | < 0.0001 |
 Dysthymic disorder (ICD 300.4) | 1007/43,115 | 1.40 (1.13, 1.74) | 0.0024 |
 Adjustment disorders (ICD 309.0, 309.1, 309.28) | 420/11,758 | 1.31 (0.90, 1.89) | 0.1586 |
 Other depressive disorder (ICD 311) | 7339/170,690 | 1.25 (1.15, 1.37) | < 0.0001 |
Other psychiatric comorbidities | |||
 No | 9880/223,979 | 1.29 (1.20, 1.39) | < 0.0001 |
 Yes | 3244/131,963 | 1.32 (1.18, 1.49) | < 0.0001 |
Self-harm | |||
 No | 13,067/354,332 | 1.29 (1.22, 1.38) | < 0.0001 |
 Yes | 57/1610 | 2.02 (1.00, 4.05) | 0.0495 |
Substance use disorder | |||
 No | 12,519/345,360 | 1.30 (1.22, 1.38) | < 0.0001 |
 Yes | 605/10,582 | 1.24 (0.95, 1.61) | 0.1136 |