Table 2 Demographic and baseline characteristics
|  | All MDD patients N = 355,942 | TRD patients N = 34,176 |
|---|---|---|
Age, mean years (SD) | 46.4 (18.01) | 44.5 (17.35) |
Charlson comorbidity score, mean (SD) | 0.063 (0.372) | 0.183 (0.630) |
Age groups, years (%) | ||
 18–24 | 40,681 (11.4) | 4686 (13.7) |
 25–34 | 68,137 (19.1) | 6669 (19.5) |
 35–44 | 69,687 (19.6) | 6970 (20.4) |
 45–54 | 63,632 (17.9) | 6344 (18.6) |
 55–64 | 46,306 (13.0) | 4369 (12.8) |
 ≥ 65 | 67,499 (19.0) | 5138 (15.0) |
Gender, n (%) | ||
 Women | 222,165 (62.4) | 21,443 (62.7) |
Depression subtype, n (%) | ||
 Major depressive disorder (ICD 296.2, 296.3×) | 130,379 (36.6) | 14,622 (42.8) |
 Dysthymic disorder (ICD 300.4) | 43,115 (12.1) | 3836 (11.2) |
 Adjustment disorders with depressive symptoms (ICD 309.0, 309.1, 309.28) | 11,758 (3.3) | 950 (2.8) |
 Other depressive disorder (ICD 311) | 170,690 (48.0) | 14,768 (43.2) |
Substance use disorder, n (%) | ||
 Yes | 10,582 (3.0) | 1263 (3.7) |
Self-harm, n (%) | ||
 Yes | 1610 (0.5) | 275 (0.8) |
Other psychiatric comorbidities, n (%) | ||
 Yes | 131,963 (37.1) | 13,743 (40.2) |