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Table 4 Relationship between PANSS score and other factors in patients with schizophrenia: multiple regression analysis

From: Multi-regression analysis revealed a relationship between l-serine and methionine, a component of one-carbon metabolism, in the normal control but not in the schizophrenia

 

Forced entry model

Backward elimination model

β ± SD

p value

VIF

β ± SD

p value

VIF

PANSS score

 Sex

−0.13 ± 0.22

0.57

2.42

   

 Age

−0.62 ± 0.32

0.06

5.04

−0.54 ± 0.15

<0.001

1.16

 Smoking status

−0.15 ± 0.20

0.44

1.91

   

 Duration of illness

0.16 ± 0.25

0.53

3.22

   

 CP equivalent dose

0.11 ± 0.18

0.52

1.38

   

 Vitamin B12

0.05 ± 0.15

0.76

1.31

   

 Folate

0.30 ± 0.19

0.12

1.73

0.35 ± 0.16

0.04

1.41

 Homocysteine

0.38 ± 0.21

0.09

2.31

0.27 ± 0.16

0.10

1.43

 l-serine

0.00 ± 0.00

1.00

3.26

   

 d-serine

0.43 ± 0.25

0.10

3.08

0.38 ± 0.14

0.01

1.07

 Glycine

−0.13 ± 0.20

0.53

2.13

   

 Methionine

0.34 ± 0.16

0.05

1.35

0.29 ± 0.15

0.07

1.29

 Genotype131

−0.29 ± 0.20

0.16

1.96

−0.25 ± 0.15

0.10

1.18

 Genotype133

−0.14 ± 0.23

0.55

2.61

   

Positive PANSS score

 Sex

−0.03 ± 0.21

0.89

2.42

−0.71 ± 0.19

<0.001

2.21

 Age

−0.68 ± 0.30

0.04

5.04

   

 Smoking status

−0.04 ± 0.18

0.82

1.91

   

 Duration of illness

0.25 ± 0.24

0.32

3.22

0.31 ± 0.19

0.11

2.07

 CP equivalent dose

0.12 ± 0.12

0.45

1.38

   

 Vitamin B12

0.14 ± 0.16

0.38

1.31

   

 Folate

0.32 ± 0.18

0.08

1.73

0.25 ± 0.14

0.08

1.12

 Homocysteine

0.31 ± 0.20

0.15

2.31

   

 l-serine

0.07 ± 0.24

0.77

3.26

   

 d-serine

0.22 ± 0.24

0.36

3.08

   

 Glycine

0.31 ± 0.20

0.13

2.13

0.47 ± 0.13

<0.001

1.06

 Methionine

0.26 ± 0.16

0.11

1.35

0.19 ± 0.15

0.20

1.25

 Genotype131

−0.32 ± 0.19

0.11

1.96

−0.23 ± 0.14

0.11

1.16

 Genotype133

−0.06 ± 0.22

0.78

2.61

   

Negative PANSS score

 Sex

−0.05 ± 0.23

0.82

2.42

   

 Age

−0.42 ± 0.34

0.23

5.04

−0.25 ± 0.15

0.11

1.07

 Smoking status

−0.18 ± 0.21

0.38

1.91

−0.27 ± 0.16

0.11

1.27

 Duration of illness

0.15 ± 0.27

0.58

3.22

   

 CP equivalent dose

0.12 ± 0.24

0.50

1.38

   

 Vitamin B12

0.05 ± 0.18

0.79

1.31

   

 Folate

0.14 ± 0.20

0.49

1.73

   

 Homocysteine

0.37 ± 0.23

0.12

2.31

0.24 ± 0.18

0.19

1.48

 l-serine

0.14 ± 0.27

0.61

3.26

   

 d-serine

0.30 ± 0.26

0.27

3.08

0.47 ± 0.19

0.02

1.73

 Glycine

−0.53 ± 0.22

0.02

2.13

−0.61 ± 0.20

0.004

1.76

 Methionine

0.28 ± 0.17

0.12

1.35

   

 Genotype131

−0.37 ± 0.21

0.09

1.96

−0.16 ± 0.15

0.30

1.10

 Genotype133

−0.31 ± 0.24

0.22

2.61

   
  1. β standardised partial regression coefficient, VIF variance inflation factor