Table 7 Weight, plasma glucose, and lipid data (safety population)
Mean (SD) change from randomization | Quetiapine | Placebo | Lithium | Paroxetine | ||||
|---|---|---|---|---|---|---|---|---|
BPI (n = 1217) | BPII (n = 632) | BPI (n = 500) | BPII (n = 242) | BPI (n = 87) | BPII (n = 49) | BPI (n = 76) | BPII (n = 45) | |
Mean weight change (kg) | 1.1 (4.8) | 1.3 (5.5) | −0.0 (2.5) | 0.1 (2.4) | 0.1 (2.1) | 0.3 (2.2) | −0.4 (3.2) | −0.0 (1.9) |
Weight change ≥ 7 %, n (%) | 85 (7.0) | 44 (7.0) | 11 (2.2) | 5 (2.1) | 2 (2.3) | 1 (2.0) | 2 (2.6) | 1 (2.2) |
Glucose (mg/dL) | 4.6 (21.5) | 3.0 (14.4) | 4.0 (20.3) | 2.4 (14.6) | 2.2 (18.9) | 2.8 (11.8) | 3.3 (13.2) | −1.9 (15.3) |
Insulin (pm/L) | 49.9 (192.7) | 27.9 (111.1) | 15.6 (142.3) | 19.1 (112.6) | 6.0 (120.1) | −18.3 (101.2) | 14.5 (83.9) | 15.0 (100.4) |
Total cholesterol (mg/dL) | −1.8 (31.9) | −0.9 (31.6) | −3.3 (27.6) | −4.9 (31.2) | −3.0 (37.9) | −9.3 (31.5) | −4.7 (37.9) | 0.3 (30.9) |
LDL-cholesterol (mg/dL) | −3.1 (28.2) | −2.8 (26.5) | −3.2 (24.3) | −5.1 (23.5) | −3.9 (32.6) | −6.8 (28.0) | −5.9 (32.8) | −3.3 (27.7) |
HDL-cholesterol (mg/dL) | −0.9 (9.4) | −1.0 (9.3) | 0.2 (8.8) | −1.3 (8.9) | −0.9 (13.3) | 0.0 (8.9) | 0.6 (12.4) | 1.1 (10.2) |
Triglycerides (mg/dL) | 18.6 (112.8) | 16.9 (85.1) | −1.1 (111.8) | 8.7 (112.2) | 2.8 (81.1) | −0.9 (62. 6) | −5.0 (106.8) | 26.9 (91.5) |