Treatment | Bipolar I n = 1162 | Bipolar II n = 598 | ||||
---|---|---|---|---|---|---|
n | Least squares MADRS score change (mean, SE) | Probabilitya | n | Least squares MADRS score change (mean, SE) | Probabilitya | |
Quetiapine | ||||||
Week 4 | 944 | −15.01 (0.27) | <.01 | 484 | −13.96 (0.38) | <.01 |
Week 8 | 781 | −19.01 (0.30) | <.01 | 422 | −18.44 (0.41) | <.01 |
Lithium | N = 87 | N = 49 | ||||
Week 4 | 74 | −11.16 (0.98) | NS | 41 | −10.46 (1.31) | NS |
Week 8 | 66 | −17.71 (1.03) | <.05 | 34 | −17.46 (1.43) | NS |
Paroxetine | n = 74 | n = 44 | ||||
Week 4 | 59 | −12.01 (1.09) | NS | 38 | −13.38 (1.36) | NS |
Week 8 | 45 | −16.54 (1.24) | NS | 31 | −15.35 (1.50) | NS |
Placebo | n = 486 | n = 231 | ||||
Week 4 | 388 | −11.31 (0.43) | – | 198 | −10.17 (0.60) | – |
Week 8 | 304 | −14.29 (0.48) | – | 164 | −14.57 (0.65) | – |