Bipolar II compared with bipolar I disorder: baseline characteristics and treatment response to quetiapine in a pooled analysis of five placebo-controlled clinical trials of acute bipolar depression

Table 3 Symptom severity at baseline in bipolar I and II subgroups (ITT population)

Symptom rating scale	Bipolar I	Bipolar II	Total
Depression
MADRS
n	1809	922	2731
Mean (SD)	29.4 (6.2)	27.8 (6.7)	28.8 (6.4)
HAM-D
n	1809	922	2731
Mean (SD)	24.5 (3.4)	24.1 (3.2)	24.4 (3.4)
Anxiety
HAM-A^a
n	1591	868	2459
Mean (SD)	18.3 (6.3)	19.0 (6.2)	18.5 (6.3)
Mania/hypomania
YMRS
n	1809	922	2731
Mean (SD)	5.2 (3.1)	4.7 (2.9)	5.1 (3.1)
Global severity of illness
CGI-S
n	1808	922	2730
Mean (SD)	4.4 (0.7)	4.3 (0.7)	4.4 (0.7)

Rating scale ranges: CGI-S: total score range 0–7; HAM-A: total score range 0–56; HAM-D: total score range 0–52; MADRS: total score range 0–60; YMRS: total score range 0–60. For all rating scales, a high score represents greater severity
CGI-S clinical global impression-severity, HAM-A Hamilton rating scale for anxiety, HAM-D Hamilton depression rating scale, 17 item, ITT intent-to-treat, MADRS Montgomery–Åsberg depression rating scale, YMRS Young Mania rating scale
^aHAM-A was not measured in Suppes et al. [25]