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Simple schizophrenia: case report and review of the literature


Simple schizophrenia remains controversial. In this study we illustrate the diagnostic complexities of the disorder by emphasizing the importance of the criterion "progressive development of odd behaviour".

Materials and methods

We report the case of a 35-year-old man with "organic mental disorder". His medical and psychiatric history notes were peer reviewed and, neuropsychological assessments (WISC and Rorschach), blood tests, EEG and Computed tomography were carried out. Several psychiatric scales (SCID, BPRS, HDS-17, CAS and GAF and MMSE) were also used to establish diagnosis and to evaluate treatment changes. We reviewed the differential diagnosis of the case, the history of simple schizophrenia and its importance both to this case and to current thought about schizophrenia.


The patient had followed a social skills training program in a community setting for two years. His current state indicates IQ: 97, attention and concentration deficits, blunting of affect, inability to meet the demands of society and decline in overall performance (GAF: 41-50, CAS: 25). Neuroimaging and laboratory tests are normal. Furthermore he meets research criteria for simple deteriorative disorder or simple schizophrenia. He is been treated with aripiprazole now, with good response.


The review of the literature (historical articles, case reports, epidemiological and trancultural surveys, studies on reliability and validity and review articles) demonstrates the heterogeneity of the simple schizophrenia diagnosis oven the years. However there is a lack of developmental and psychopathological approaches that could provide a better understanding on the disorder. More case reports may contribute to that.


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Correspondence to Sofia Efstratiou.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Efstratiou, S., Tzavaras, N. Simple schizophrenia: case report and review of the literature. Ann Gen Psychiatry 9, S183 (2010).

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  • Schizophrenia
  • Social Skill
  • Aripiprazole
  • Neuropsychological Assessment
  • Progressive Development