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Evaluation of pharmacotherapy in inpatients with mania in bipolar disorder


The studies concerning prophylactic treatment in bipolar disorder suggest it should be introduced after the first manic episode [1]. Also early polytherapy is promoted, mainly mood stabilizers and antipsychotics. Antipsychotics are recommended in short-term use [2], but they are also used after improvement. Typical antipsychotics are effective in monotherapy in 70% of patients, like mood stabilizers.[3] The combination of antipsychotics and mood stabilizers is superior to monotherapy in rapid control of agitation.

Materials and methods

We determined which drugs are chosen at Institute of Psychiatry and Neurology for treating and preventing manic episodes. 61 inpatients diagnosed with manic episodes were evaluated.At discharge, 28% of patient were ordered to take one drug. For 72% patients polytherapy was ordered.


There was no difference in the number of disease or manic phases between the group of patients with a remission phase lasting for at least a year and less than a year. Recurrence within one year after discharge was twice as frequent in patients with polytherapy than with monotherapy. During polytherapy the probability of avoiding recurrnce was dropping quickly.No dependence was observed between the number of recurrences at patients with monotherapy or polytherapy and such parameters as the number of manic episodes, the number of depression episodes or education.


In most inpatients polytherapy was applied. For the maintenance phase of treatment the same drugs were recommended as used for active treatment. The way of treatment fully corresponds to bipolar disorder treatment standards.


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Corresponding author

Correspondence to Agnieszka Piróg-Balcerzak.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Piróg-Balcerzak, A., Rzewuska, M., Luks, M. et al. Evaluation of pharmacotherapy in inpatients with mania in bipolar disorder. Ann Gen Psychiatry 9, S102 (2010).

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  • Public Health
  • Bipolar Disorder
  • Treatment Standard
  • Active Treatment
  • Prophylactic Treatment