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Table 7 Factors significantly associated with EQ-5D HSI over 6 months of AD treatment

From: The Factors Influencing Depression Endpoints Research (FINDER) study: final results of Italian patients with depression

Independent variables

F, P value

Estimate

95% CI

HSI at baseline

32, < 0.0001

0.208

0.136 to 0.280

Switch within or between AD class (2 df) (reference no switch)

11, < 0.0001

Between -0.071 Within -0.222

-0.136 to -0.006 -0.323 to -0.121

SSI-somatic at baseline

12, < 0.001

-0.062

-0.098 to -0.026

No. of previous episodes of depression

9, 0.002

-0.022

-0.036 to -0.008

Any chronic medical conditions (yes vs no)

8, 0.005

-0.055

-0.094 to -0.017

Overall pain VAS at baseline

8, 0.005

-0.001

-0.002 to -0.0003

No. of dependants

7, 0.010

0.018

0.004 to 0.032

HADS-A at baseline

6, 0.019

0.008

0.001 to 0.013

  1. No. of patients = 328, no. of observations = 650. Switch = change between what was taken between baseline and 3-month observation and what was taken between the 3-month and 6-month observations.
  2. AD = antidepressant; df = degrees of freedom; EQ-5D = European Quality of Life-5 Dimensions; HADS-A, Hospital Anxiety and Depression Scale - anxiety; HSI, health status index; SSI = Somatic Symptom Inventory; VAS = visual analogue scale.