Table 2 Characteristics of the studies included in the review
From: Review of the use of Topiramate for treatment of psychiatric disorders
Condition | Number of studies | Design | Outcome |
|---|---|---|---|
Bipolar disorders | Â | Â | Â |
Bipolar mania | 8 | 5 controlled (*) | Negative |
|  |  | 3 open label (70–72) | Positive |
Rapid-cycling bipolar disorders | 1 | Open label, add-on (75) | Positive |
Adjunctive therapy (refractory bipolar disorders) | 12 | Open label (76–87) | Positive |
Bipolar depression | 2 | 1 Controlled, add-on (88) | Positive |
| Â | Â | 1 Open label, add-on (89) | Positive |
Bipolar disorders in children and adolescents as adjunctive treatment | 1 | Open label, add-on (90) | Positive |
Unipolar depression | 2 | 1 Case report (91) | Negative |
| Â | Â | 1 Chart review (92) | Positive |
Schizophrenia, schizoaffective disorders and psychosis unspecified | 3 | 2 Case series (93, 94) | Negative |
| Â | Â | 1 Case report (95) | Positive |
Eating disorders and disordered eating | 4 | 2 Controlled (96, 97) | Positive |
| Â | Â | 1 Open label, add on (98) | Positive |
| Â | Â | 1 Case series, add on (99) | Positive |
Posttraumatic stress disorder | 1 | Open label, add on (100) | Positive |
Alcohol dependence | 1 | Controlled (101) | Positive |
Gilles de la Tourette's syndrome | 1 | Case series (102) | Positive |
Emotional unstable personality disorder | 1 | Case reports (103) | Positive |