Receptor | Risperidone | Olanzapine | Quetiapinea | Ziprasidone | Clozapine | Aripiprazole | Haloperidol | |
---|---|---|---|---|---|---|---|---|
Receptor binding affinity expressed as equilibrium constant (Ki)b | ||||||||
 D2 | 1.6 [25] | 4 [27] | 11 [27] | 160 [27] | 5 [27] | 126 [27] | 0.45 [27] | 0.7 [27] |
 5-HT2A | 1.1 [25] | 0.5 [27] | 4 [27] | 295 [27] | 0.4 [27] | 16 [27] | 3.4 [27] | 45 [27] |
 α1 | 2.5c[25] | 0.7 [27] | 19 [27] | 7 [27] | 10 [27] | 7 [27] | 57 [27] | 6 [27] |
 α2d | 3.9e[25] | 3 [27] | 230 [27] | 87 [27] | – [27] | 8 [27] | – [27] | 360 [27] |
 H1 | 19 [25] | 20 [27] | 7 [27] | 11 [27] | 47 [27] | 6 [27] | 61 [27] | 440 [27] |
 M1 | >10,000 [25] | >10,000 [27] | 1.9 [27] | 120 [27] | >1,000 [27] | 1.9 [27] | >10,000 [27] | >1,500 [27] |
Pharmacokinetic profiles, half-life | ||||||||
 t1/2, h | 23f[28] | 3 [29] | 20–70 [30] | 5–8 [30] | 4–10 [30] | 6–33 [30] | 48–68 [30] | 20 [31] |
 Tmax, h | 24 [28] | 1–2 [29] | 5–8 [32] | 4–6 [35] | 0.4–4.2 [36] | 3–5 [37] | 4.9 [38] | |
 Bioavailability, % | 28 [28] | 70 [29] | 60–80 [30] | 9 [39] | 60 [30] | 12–81 [30] | 44–74 [31] |