Figure 3
From: Definitions and drivers of relapse in patients with schizophrenia: a systematic literature review
Potential drivers of relapse. Adherence problems [2, 6, 7, 13, 17, 25, 26, 31],[34, 45, 47, 53, 57, 76, 85, 100–105]; stress, depression, depressive symptoms, neurosis [2, 6, 7, 12, 55, 59, 70, 97],[106–108]; substance abuse [2, 6, 7, 21, 31, 57, 59, 83],[97]; lifestyle factors [7, 12, 21, 38, 79, 109, 110]; hospitalization or relapse history [21, 31, 38, 40, 57, 59, 97]; treatment-related issues [6, 7, 28, 43, 61, 70, 111]; treatment interruption or delay [2, 6, 12, 75, 85, 112, 113]; disease-related factors [57, 70, 83, 85, 97, 114]; quetiapine, anticholinergics, mood stabilizers (MS), oral neuroleptics, anxiolytics or hypnotics [21, 31, 51, 55]; male gender [30, 37, 83, 115]; use of first-generation antipsychotics (FGA) vs second-generation antipsychotics (SGA) [30, 85, 116]; outpatient vs inpatient [29, 39]; poor patient insight [20, 83]; younger age [57, 83]; generic vs branded medication [117]; reduced compliance/family involvement in Information Technology Aided Relapse Prevention in Schizophrenia (ITAREPS) programme [53]; depot antipsychotics [76].