Skip to main content

Table 2 Clinical and demographic characteristics of SRI-refractory OCD patients treated with agomelatine 50 mg/day for a minimum of 3 months

From: Switching from serotonin reuptake inhibitors to agomelatine in patients with refractory obsessive-compulsive disorder: a 3 month follow-up case series

 

Patient 1

Patient 2

Patient 3

Patient 4

Patient 5

Patient 6

Age

35

44

66

53

25

33

Age at onset

23

36

57

20

15

24

Gender

M

M

F

F

M

F

DSM-IV Axis-I comorbidities

Resistant MDD, social anxiety disorder

Impulse-control disorder, substance abuse disorder

None

Bulimia nervosa, panic disorder

None

Panic disorder

First-degree relatives family history

Bipolar disorder II (brother)

ADHD (son)

None

None

None

None

Side effects

Weight gain (BMI 32 to 34 within 3 months)

None

None

None

None

Dizziness (initial, spontaneously remitting)

Last failed SRI trial

Fluoxetine 60 mg/day

Sertraline 200 mg/day

Fluoxetine 60 mg/day

Amitriptyline 300 mg/day

Fluvoxamine 250 mg/day

Duloxetine 120 mg/day + CBT

Main clinical features/OC symptoms

Doubt/compulsive shopping

Belching compulsion

Religious/touching

Hoarding/insertion of thought and intrusive images with sexual contents/checking

Checking/repeating

Fear of losing control toward food (in absence of BED)

Y-BOCS total score (baseline to week 12)

Not modified

Remission: 21 to 9

Not modified

Not modified

Remission: 32 to 11

Remission: 22 to 8

Actual, subjective circadian rhythms impairment (BRIAN)

Any relevant disruptions

Reported stable insomnia

Any relevant disruptions

Any relevant disruptions

Reported daily hypersomnia and nocturnal awakening

Any relevant disruptions

Lifetime bipolar spectrum signs (TEMPS-A at week 12)

Cyclothymic temperament

Anxious temperament

Any specific

Cyclothymic temperament

Any specific

Any specific (but presence of PD)

Poor insight feature (BABS, baseline-week 12)

No (stable)

Yes→No

No (stable)

No (stable)

No (stable)

No (stable)

  1. Patient 6 received CBT within the 3 month trial with agomelatine; psychotherapy had already been established at least 6 months earlier.
  2. ADHD = attention deficit hyperactivity disorder; BABS = Brown Assessment of Beliefs Scale; BED = Binge Eating Disorder; BMI = body mass index; BRIAN = Biological Rhythms Interview of Assessment in Neuropsychiatry; CBT = cognitive behavioral therapy; DSM-IV = Diagnostic and Statistical Manual of Mental Disorders, fourth edition; MDD = major depressive disorder; SRI = serotonin reuptake inhibitor; OC = obsessive compulsive; PD, panic disorder; TEMPS-A = Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego lifetime Autoquestionnaire; Y-BOCS = Yale-Brown Obsessive Compulsive Scale.